益智灵冲剂对实验性老年痴呆病理模型的作用

Effect of Yizhiling Granule on Experimental Pathological Model of Alzheime's Disease

选用60只LACA小白鼠,口服氯化铝造成老年痴呆模型,用中药益智灵冲剂进行治疗,观察脑记忆功能及脑组织重量(脑重)变化。结果表明:益智灵冲剂可使痴呆小白鼠的记忆功能改善,脑重恢复正常水平。说明益智灵冲剂对老年痴呆具有一定的疗效。

Alzheimer's disease is an important problem of gerontology which manifested as serious loss ofmemory, especially of recent memory, decrease of brain weight. The pathological model of thedisease in mice was made with administration of AlCl_3 and then Yizhiling Granule was given to treatit. Results: In the experiment of one trial passive avoidance response there were significant differ-ence between the normal group and the model group (P<0.01) and significant difference betweenthe treated group and the model group (P<0.05-0.01); as for fresh brain weight, the treated groupwas significantly different from the normal group (P<0.01) and model group (P<0.05). Theyindicate that Yizhiling Granule could improve memory and increase brain weight. This researchseems to provide experimental. basis for treatment of the disease.