舍格伦综合征个性心理及中枢神经系统改变的研究

Psychiatric and central nervous system involvement in Sj gren′s syndrome

目的 探讨中国原发性舍格伦综合征 (primarySj gren′ssyndrome ,PSS)患者个性心理特点及中枢神经系统的改变。方法 用明尼苏达多项个性调查表 (简称MMPI)测试 30例PSS患者和 5 7名健康女性 ,并将两者比较 ;10例患者分别进行脑电图 (electroencephalography ,EEG)、经颅三维多普勒 (transcranialdopplerultrasound ,TCD)和核磁共振 (magneticresonanceimaging ,MRI)的检查。结果 测试有效的 2 7例患者处于前 3位的量表是疑病 (hypochondriasis ,Hs)、癔病 (hysteria ,Hy)和精神衰弱 (psychasthenia ,Pt) ,且Hs、Hy的T分明显高于健康女性 ;9例行EEG者 3例异常 ,9例行TCD者 5例异常 ,1例MRI异常。结论 PSS患者的个性特点为神经质样个性 ,其中枢神经系统亦有改变 ,而且心理异常与神经系统异常之间有显著相关性 ,后者可能是前者的病理学基础。

Objective To study psychiatric features and the manifestations of central nervous system involvement in Chinese patients with primary Sjogren′s syndrome (PSS) Methods The Minnesota Multiphasic Personality Inventory (MMPI) was used to study 27 PSS female patients and 57 healthy women The results from two groups were compared Ten SS patients were evaluated by electroencephalography (EEG), transcranial doppler ultrasound (TCD) and magnetic resonance imaging (MRI) Results Of 27 patients tested, the three highest clinical mean scales included Hypochondriasis (Hs), Hysteria (Hy), Psychasthenia (Pt ) were found When PSS group was compared with normal control, T scores of SS patients were significantly higher than the healthy women in Hs, Hy Abnormal EEG was found in 3 of 9 PSS patients TCD was abnormal in 5 of 9 patients MRI in 1 patient showed abnormality Conclusions This study shows that the personality of PSS patients is abnormal, the features are neuroticism Central nervous system was markedly involved in Chinese patients with PSS, including abnormal EEG and TCD The changes of central nervous system may be related to abnormalities of psychiatric changes