献血员戊型肝炎病毒亚临床感染情况调查

Investigation of sub-clinical infection of hepatitis E virus in blood donors

目的 了解献血员中戊型肝炎病毒(HEV)亚临床感染情况。 方法 对2002年7～8月向北京市血液中心义务献血的所有人员进行整群抽样,检测抗-HEV IgM和IgG抗体。 结果 北京献血员中抗-HEV IgM阳性率为1.74％,其丙氨酸氨基转移酶(ALT)异常比例高于抗-HEV IgM阴性献血员。ALT异常与HEV相关的比例为2.68％,与HBV相当,但高于丙型肝炎病毒。 结论 献血员中存在HEV亚临床感染者,并且是献血员中ALT异常的原因之一。

Objective To understand the prevalence of sub-clinical infection of hepatitis E virus (HEV) among blood donors. Methods A cluster sampling strategy was used to sample all blood donors from July to August in 2002 in Beijing. Their blood was tested for IgM and IgG antibody against HEV. Results The prevalence of anti-HEV IgM among blood donors in Beijing was 1.74%. The rate of abnormal alanine aminotransferase (ALT) in anti-HEV IgM positive donors is significantly higher than anti-HEV IgM negative donors. Among all ALT abnormal donors, 2.68% can be associated with HEV sub-clinical infection. The percentage is similar with HBV but higher than HCV. Conclusion There are sub-clinical infection of HEV among blood donors, which is one of the cause of abnormal ALT in the donors.