血浆内皮素、一氧化氮与妊娠高血压综合征眼底视网膜血管病变关系的临床研究

Relationship between endothelin and nitric oxide in plasma with retinopathy in the pregnancy-induced hypertension

目的 探讨血浆内皮素 (ET)、一氧化氮 (NO)在妊娠高血压综合征 (PIH)眼底视网膜血管病变发病中的作用。 方法 采用放射免疫分析法检测 75例住院 PIH患者和 2 0例正常足月妊娠待产产妇产前和产后血浆 ET、NO水平 ,同时专人检查 PIH患者产前、产后眼底视网膜病变情况 ;对比分析 PIH患者与正常足月妊娠待产妇血浆 ET、NO水平的差异以及 PIH患者产前、产后血浆 ET、NO水平变化与眼底改变之间的关系。 结果 重度 PIH组患者血浆 ET为 (14 5 .0 0± 5 4 .4 1) ng/ L ,明显高于正常妊娠组和轻、中度 PIH组 [ET分别为 (81.5 0± 4 3.80 )、(85 .30± 33.33)、(90 .2 0± 39.2 5 ) ng/ L];PIH患者产后血浆ET为 (118.70± 33.4 4 ) ng/ L,较其产前无显著性变化 ,但仍明显高于正常妊娠组。重度、中度 PIH组血浆NO分别为 (87.5 6± 35 .5 8)、(78.11± 2 8.96 ) ng/ L ,均明显高于正常妊娠组 [(46 .70± 32 .6 4 ) ng/ L ];轻度PIH组血浆 NO为 (5 2 .5 6± 2 8.35 ) ng/ L,轻度、中度 PIH组血浆 NO水平明显低于重度 PIH组 ;PIH患者产后血浆 NO水平较其产前明显降低 ,但仍明显高于正常妊娠组。 PIH患者血浆 ET、NO水平随眼底视网膜病变的加重而升高。 结论 PIH患者血浆 ET、NO水平与 PIH病情严重程度有关 ,血?

Objective To explore the effect of endothelin (ET)、nitric oxide (NO) in plasma on retinopathy in the pregnancy-induced hypertension (PIH). Methods The level of ET and NO in plasma of 75 cases of in-patient women with PIH and 20 cases of women with the full terms and normal pregnancy before and after delivery was determined by radioimmunoassay. The retinopathy of the patients with PIH before and after delivery was detected by appointed doctor. The levels of ET and NO in both groups were compared and the relationship between ET and NO in plasma and the retinopathy before and after the delivery was detected. Results The levels of ET [(145.00±54.41) ng/L] in serious PIH patients were much higher than that in the control [(81.50±43.80) ng/L], the minor [(85.30±33.33) ng/L] and middling PIH group [(90.20±39.25) ng/L]. The levels of ET in plasma before and after pregnancy were not changed in PIH patients [(118.70±33.44) ng/L], but were higher than that in the control group. The levels of plasma NO in serious [(87.56±35.58) ng/L] and middling [(78.11±28.96) ng/L] PIH group were both higher than that in the control group [(46.70±32.64) ng/L], and the levels in minor[(52.56±28.35) ng/L] and middling PIH group were lower than that in the serious PIH group. The level of NO in plasma of PIH patients after the delivery was much lower than that before the delivery, while higher than that in the control. The positive correlation between levels of ET and NO and retinopathy was found in PIH patients. Conclusions The levels of plasma ET and NO in PIH patients are related to the extent of the disease, and the level of ET in plasma is highly related to the retinopathy in PIH patients. ET and NO might be played an important role in pathogenesis of retinopathy and ET might be a good index in reflecting the rank of retinopathy in PIH.