摘要
黄芪皂甙AMS,50~200μg/ml对离体工作鼠心有正性肌力作用,30μg/ml呈负性肌力作用,洗脱后恢复。毒毛旋花子甙K与高浓度AMS作用相似。AMS 500μg/ml使培养鼠心肌细胞静息电位减小10mV。提示AMS通过Na-K-ATP酶实现强心作用。
Astragalus membranaceus saponins (AMS) 50~200μg/ml had a positive inotropic action on the isolated working heart of rats, but in the case of 30 μg/ml the inotropic action turned negative. The contractility recovered after washing out the AMS. Strophanthin K performed in a similar manner as AMS. AMS 500 μg/ml decreased the resting potential of cultured rat heart cells by 10 mV. The results suggest that AMS plays its inotropie role through influencing the Na-K-ATPase.
出处
《中国中药杂志》
CAS
CSCD
北大核心
1992年第9期557-559,共3页
China Journal of Chinese Materia Medica
关键词
黄芪
皂甙
心脏
肌力作用
Astragalus membranaceus saponins
isolated working heart
cultured cardiomyocvtes
inotropic action
resting potentials