黄芪皂甙对离体工作心脏的肌力作用及其可能机制

Inotropic Action of Astragalus membranaceus Bge. Saponins and Its Possible Mechanism

黄芪皂甙AMS,50～200μg/ml对离体工作鼠心有正性肌力作用,30μg/ml呈负性肌力作用,洗脱后恢复。毒毛旋花子甙K与高浓度AMS作用相似。AMS 500μg/ml使培养鼠心肌细胞静息电位减小10mV。提示AMS通过Na-K-ATP酶实现强心作用。

Astragalus membranaceus saponins (AMS) 50～200μg/ml had a positive inotropic action on the isolated working heart of rats, but in the case of 30 μg/ml the inotropic action turned negative. The contractility recovered after washing out the AMS. Strophanthin K performed in a similar manner as AMS. AMS 500 μg/ml decreased the resting potential of cultured rat heart cells by 10 mV. The results suggest that AMS plays its inotropie role through influencing the Na-K-ATPase.