血浆抵抗素与多囊卵巢综合征患者胰岛素抵抗的关系

The Correlation Between Plasma Resistin with Insulin Resistance in Polycystic Ovary Syndrome

目的 :探讨血浆抵抗素 (resistin)水平与多囊卵巢综合征 (PCOS)胰岛素抵抗的关系。方法 :采用ELISA方法检测 30例PCOS患者及 35例正常对照组空腹血浆抵抗素浓度 ,并采用放射免疫法检测黄体生成激素 (LH)、卵泡刺激素(FSH)及空腹胰岛素 (FIN) ,用氧化酶法检测空腹血浆葡萄糖 (FPG)浓度 ,计算胰岛素抵抗指数 (HOMA IR)。结果 :①PCOS组血浆抵抗素、LH、LH/FSH、FIN、HOMA IR均显著高于对照组 (均P <0 0 5 ) ;②PCOS组血浆抵抗素与FPG、FIN、HOMA IR、LH及LH/FSH呈显著正相关 (r分别为 0 5 8、0 6 1、0 6 4、0 4 7、0 4 1)。结论 :抵抗素参与了PCOS胰岛素抵抗的发生过程 ;

Objective: To investigate the relationship between plasma resistin and insulin resistance in polycystic ovary syndrome. Methods : The plasma resistin concentration of 30 patients with PCOS and 35 cases of normal control were measured by ELISA. LH,LH/FSH radio,fasting insulin(FIN) and fasting plasma glucose(FPG) detection were analyzed by radioimmunoassay or oxidase test,and HOMA_IR was calculated. Results: ①The levels of plasma resistin, LH,LH/FSH ratio, serum FIN level,and HOMA-IR in patients with PCOS were significantly higher than those in control group(P<0.05);②Plasma resistin correlated positively with FPG,FIN,HOMA-IR,LH,and LH/FSH ratio, (r=0.58,0.61,0.64,0.47,0.41, respectively). Conclusions: Plasma resistin play a role in the pathogenesis of insulin resistance and related intimately to PCOS.Plasma resistin may be used as a new sensitive marker to evaluate the degree of insulin resistance in PCOS.