妊娠肝内胆汁淤积症与胎儿生长受限关系的探讨

The Relationship between the Intrahepatic Cholestasis of Pregnancy and the Fetal Growth Retardation

目的 :探讨妊娠肝内胆汁淤积症 (ICP)与胎儿生长受限 (FGR)的关系。方法 :回顾性分析 6 1例ICP患者与对照组妊娠结局、新生儿体重、FGR发生率的比较及ICP新生儿体重与胆汁酸、肝功能的关系。结果 :ICP组早产、羊水粪染、Apgar评分 <7分 (1分钟 )的发生率与对照组比较差异有非常显著性 ,P <0 .0 1。ICP组新生儿平均体重为 (32 33.9±14 75 .5 )g ,FGR的发生率为 3 3% ,与正常组相比差异无显著性。多元线性回归分析 ,ICP组新生儿体重与胆汁酸、肝功能无明显线性关系。结论

Objective: To study the relationship between the intrahepatic cholestasis of pregnancy (ICP) and the fetal growth retardation (FGR). Methods: A respectively method was applied to analysis the weight of new-born, serum bilirubin, and liver function in 61 patients with ICP and another 61 normal pregnant women as controls, and to demonstrate the relationship between the weight of new-born and serum bilirubin or liver function. Results: The occurrence of preterm birth, meconium in amnion, and neonatal Apgar Scores were lower in ICP group than those in controls. The mean weight of new-born was 3233.9 ±1475.5 g in ICP group and the prevalence of FGR was 3.3% which was similar to controls. There was no relationship between the weight of new-born and serum bilirubin and liver function by multi-factor lineal analysis. Conclusions: There is no adverse effect of ICP on the fetal growth.