人乳腺癌雌激素受体和孕酮受体与外周血性激素水平的关系

Estrogen and Progesterone Receptor Levels in Human Breast Cancer in Relaticn to Circulating Sex Hormone Levels

测定了30例未绝经和73例的绝经后乳腺癌妇女的雌激素受体(ER)、孕酮受体(PR)和外周血雌酮(E_1)、雌二醇(E_2)、孕酮(P)和睾酮(T)水平。结果表明:(1)乳腺癌病人外周血E_1和P水平在ER_+组和ER+PR-组明显高于ER-组和ER-PR-组(P<0.05)。(2)乳腺癌病人外周血E_2水平在PR+组和ER^+PR^+组明显高于PR-组和ER-PR-组(3)乳腺癌病人术后生存期与外周血T水平有关,ER-组和PR-组乳腺癌病人中,术后生存期≥5年组和术后生存期<5年组之间外周血T水平有显著差异(P<0.05,P<0.001)。

Concentration of estrogen receptor (ER), progesterone receptor (PR) in tumor tissue and plasma levels of estrone(E1), estradio1 (E2), progesterone (P) and testos- terone (T) in 30 premenopat sal and 73 postmenopausal women with breast cancer were determined. The restlts indicated that (A) The serum levels of El and P in the groups of ER+and ER+PR- patients were significantly higher than those of ER- and ER-PI- patients (P<0.05). (B) The levels of serum E2 in the groups of PR+ and ER+PR+ patients were significantly higher than those of PR- and ER-PR- patients (P<0.05). (C) The pcstoperative survival of patients with breast cancer did correlated with the plasma sex hcrmone levels. The plasma T level was signifi- cantly different between the gretp of≥5-year survival and the group of<5-year strvival in ER-and PR-patients treated by radical mastectomy (P<0.05, P<0.001).