甲状腺乳头状癌的生长与女性激素受体及血清激素水平相关的研究

Estrogen and Progesterone Receptor of Thyroid Cancer

本研究采用酶联亲和组化法,对151例甲状腺各种病变及正常组织,进行了探索性地雌激素受体(ER)和孕激素受体(PgR)检测,并对其中43例乳头状癌患者的5种相关血清激素进行放免测定。结果显示:甲状腺各种病变组织及正常组织中,多可查见例数不等和含量不同的女性激素受体,其中以乳头状癌分布最广(占病例的90％以上),且阳性率最高(ER44.O％,PgR64.0％);女性乳头状癌组织的PgR阳性率(71.0％)高于男性(52.6％),血清雌二醇及孕酮的均值(48·87Pg/ml及1.55ng/ml)均显著高于男性(25.79Pg/ml及0.43ng/ml,P<0.001及P<0.05)。本研究首次提示甲状腺乳头状癌组织中有ER和PgR并存,为本病属女性激素依赖性肿瘤及女性激素可能致癌,提供参考依据。

Estrogen receptor (ER) and progesterone receptor (PgR) were measured using enzyme-linked histochemical technique in 151 specimens of various thyroid diseases. The serum level of female sex hormones (E_2, Pg) and other hormones (TSH, T_3, T_4) related to thyroid were determined by radioimmunoassay in 43 cases of papillary thyroid carcinoma. ER and PgR were identified in most of the neoplastic and nonneoplastic tissues. Papillary thyroid carcinoma had higher amount of receptors than did other lesions. The frequency of presence of EK and PgR in papillary carcinoma, adenoma and goiter were 44.0% (22/50) and 64.0% (32/50), 4.6% (3/64) and 10.9% (7/64), 12.5% (2/16) and 12.59% (2/16) respectively. Radioimmunoassay revealed that in female patients higher, level of serum estradiol (48.87 pg/ml) and progesterone (1.55ng/ml) were observed than the male (25.79 pg/ml) and 0.43ng/ml). This study demonstrated that papillary thyroid carcinoma contains high value of both ER and PgR, suggesting a role in the development in female of neoplastic thyroid diseases.