生化指标对原发性肝癌患者生存期的影响

Evaluation of Prognostic Significance of Some Biochemical Parameters in Patients with Primary Liver Cancer

本文评价了原发性肝癌各项生化指标对其生存期的影响。分析结果表明,甲胎蛋白放免火箭电泳、对流免疫电泳及间接反向血凝法,三种测定方法的阳性率分别为53.8％,40.6％;43.3％,其对肝癌的预后无影响。谷-丙转氨酶,碱性磷酸酶、胆红素、综合指标白蛋白/球蛋白比值对原发性肝癌的预后有影响。P<0.01和0.05。应用逐步COX回归方法筛选了影响肝癌生存期的主要因素,结果显示碱性磷酸酶和胆红素为影响肝癌生存期的主要因素,两者具有相乘作用(P=0.0000)。

The prognostic significance of several biochemical assays in 366 hepatic cancer patients were evaluated.The positive rates of alpha-fetoprotein by three assay methods (Rocket Electrophoresis,Convection Electrophoresis and Indirect Agglutination) were 53.8%,40.6%,43.3% respectively.No statistical significance was found for measures of serum TTT,alpha-fetoprotein,HAA,albumin and globulin of any value in indicating prognosis.Patients with positive serum GPT,AKP,bilirubin and lower albumin/globulin ratio had worse prognosis.The result of stepwise Cox regression analysis showed that AKP and bilirubin were the two parameters that bear prognostic significance among those evaluated in this work.