血清及胸水铁蛋白测定对肺癌诊断的价值

Diagnostic Significance of Ferritin Measurement in Patients with Lung Cancer

本文测定健康成人血清铁蛋白浓度(SP)113例,其中男性53例,女性60例,SF分别为93.68±56.54μg/L,60.01±30.69μg/L;男女性别间有明显差异(P<0.01)。测定疾病组SF102例,其中肺炎34例为139±31.91μg/L;结核37例为141.24±41.74μg/L;肺癌31例为459.29±92.43μg/L。各疾病组男女之间SF无明显差异。凡SF超过300μg/L者应高度怀疑恶性肿瘤。癌性胸水铁蛋白明显高于结核性胸水,超过500μg/L应考虑癌性胸水。血清及胸水铁蛋白测定可作为炎症、结核、肺癌的鉴别诊断标志之一。

Serum ferritin(SF)was determined in 113 healthy adults, 53 males and 60 females. The values for males and fe- males were 93.68±56.54μg/L and 60.01±30.69μg/L respectively with statistically significant difference (P< 0.01).The contents of SF in various lung diseases including pneumonia(34 cases),T. B. (37 cases),and lung cancer (31 cases) were also measured in the order of 139±31.91μg/L, 141.24±41. 74μg/L,and 459.29±92.43μg/L respectively. There was no marked difference as to sex in individual with lung disease. It would be highly suspicious of having malignant tumor if SF content was higher than 300μg/L. Ferritin content in pleural fluid was measured in patients with lung cancer and Tbc. It showed that pleural fluid in patient with lung cancer contained remarkablely higher ferritin than those of Tbc. Lung cancer should be considered whenever the pleural fluid contained 500μg/L or more of ferritin. SF and TF could be regarded useful in the differential diagnosis of lung cancer from pneumonia or T. B.