304例胃粘膜活检中幽门弯曲菌和胃粘膜病变关系的探讨

Relationship between Campylobacter Pyloridis and Pathologic Lesions in Gastric Mucosa

对304例有上消化道临床症状的胃粘膜活检标本进行了H—E,Wathin—starry染色,10例进行了透射电镜观察,66例进行了HID—AB—PAS染色。结果:幽门弯曲菌的感染率为54.9％;慢性活动性胃炎及溃疡病与幽门弯曲菌关系密切;幽门弯曲菌与大肠型上皮化生的复合率以慢性萎缩性胃炎最高(41.9％)。细菌位于胃粘膜表面的粘液深层,炎性渗出物及颈腺内。透射电镜可见幽门弯曲菌存在部位微绒毛损伤,粘液颗粒溶解。

Gastroendoscopic biopsy specimens from 304 patients were stained with HE and Wathin-Starry method. Ten samples were processed by TEM. Sixty-six samples were stained by HID-AB pH2. 5-PAS method. Campylobacter pyloridis(CP) was found in 167 specimens (54. 9%)and was higher in the chronic active gastritis and ulcer disease. The coincident rate of CP and large intestinal epithelium metaplasia was highest in the chronic atrophic gastritis(41. 9%). Bactrerias were found in the deeper part of mucous layer on the surface of the gastric mucosa as well as in the neck of the glands. Under electronmicroscope in areas where the CP was present, the microvilli were jeopardized and the mucoid granules underwent lytic changes.