舒肝丸对大鼠急性肝损伤的保护作用及对胆汁分泌的影响

Protective action of Shuganwan on acute liver injury and its effect on bile secretion in rats

目的 研究舒肝丸对肝损伤的保护作用 ,以及对胆汁分泌的影响。方法 用四氯化碳致大鼠急性肝损伤 ,以生化指标和病理变化评价舒肝丸的药物作用。以胆总管插管引流法观察药物对胆汁分泌的影响。结果 与模型对照组比较 ,舒肝丸给药组AST、ALT及胆红素指标明显下降 ,白蛋白与球蛋白比值 (A/G)倒置明显改善 ;病理切片显示各给药组与病理模型组比较 ,肝组织损伤明显减轻。舒肝丸给药前后对胆汁分泌量无明显影响。结论 舒肝丸对四氯化碳所致的大鼠急性肝损伤有保护作用 。

Objective To study the protective action of Shuganwan on liver injury and its cholagogue action. Methods Acute liver injury was induced by carbon tetrachloride in rats. The biochemical indexes and pathological changes were used for evaluation. The cholagogue action was studied by biliary drainage method. Results Compared with those of the CCl 4 control group, aspartate aminotransferase (AST), alanine aminotransferase (ALT) and bilirubin levels of Shuganwan group declined significantly, and albumin/ globulin (A/G) inversion was obviously improved. The pathological changes revealed that liver injury was relieved. There was no change in bile secretion after administration of Shuganwan. Conclusion Shuganwan has protective action on acute liver injury by carbon tetrachloride, but no promotive action on bile secretion.