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Role of Ran GTPase in cell cycle regulation 被引量:2

Role of Ran GTPase in cell cycle regulation
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摘要 Ran, a member of the Ras GTPase superfamily, is a multifunctional protein and abundant in the nucleus. Many evidences suggest that Ran and its interacting proteins are involved in multiple aspects of the cell cycle regulation. So far it has been conformed that Ran and its interacting proteins control the nucleocytoplasmic transport, the nuclear envelope (NE) assembly, the DNA replication and the spindle assembly, although many details of the mechanisms are waiting for elucidation. It has also been implicated that Ran and its interacting proteins are involved in regulating the integrity of the nuclear structure, the mRNA transcription and splicing, and the RNA transport from the nucleus to the cytoplasm. In this review we mainly discuss the mechanisms by which Ran and its interacting proteins regulate NE as-sembly, DNA replication and spindle assembly. Ran, a member of the Ras GTPase superfamily, is a multifunctional protein and abundant in the nucleus. Many evidences suggest that Ran and its interacting proteins are involved in multiple aspects of the cell cycle regulation. So far it has been conformed that Ran and its interacting proteins control the nucleocytoplasmic transport, the nuclear envelope (NE) assembly, the DNA replication and the spindle assembly, although many details of the mechanisms are waiting for elucidation. It has also been implicated that Ran and its interacting proteins are involved in regulating the integrity of the nuclear structure, the mRNA transcription and splicing, and the RNA transport from the nucleus to the cytoplasm. In this review we mainly discuss the mechanisms by which Ran and its interacting proteins regulate NE as-sembly, DNA replication and spindle assembly.
出处 《Chinese Science Bulletin》 SCIE EI CAS 2004年第6期535-541,共7页
关键词 RAN GTPASE 细胞循环 DNA复制 纺锤体集成 细胞核 细胞膜 G蛋白 Ran GTPase, cell cycle, DNA replication, nuclear enve-lope assembly, spindle assembly. DOI: 10.1360/03wc0541
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