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盐酸氮斯汀与氯雷他定随机对照治疗变应性鼻炎的临床试验 被引量:4

Randomized controlled clinical trial on azelastine hydrochloride tablet versus loratadine in the treatment of allergic rhinitis
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摘要 目的 与对照药氯雷他定片比较,评价盐酸氮(?)斯汀片治疗变应性鼻炎的临床疗效及安全性。方法 用多中心、随机、双盲、平行对照的临床试验,试验组变应性鼻炎病人58例,每日服用盐酸氮(?)斯汀片2次,每次1 mg;对照组病人63例,每日口服氯雷他定片1 0 mg和安慰剂各1次。两组均连续服药14天。对治疗前后的喷嚏、流涕、鼻堵、鼻痒及鼻腔情况进行评分。结果 盐酸氮革斯汀片和氯雷他定片治疗变应性鼻炎的有效率分别为87.93%,82.54%;药物不良反应发生率分别为8.62%,14.06%。经统计学检验,两者差异均无显著性。 结论 盐酸氮(?)斯汀片治疗变应性鼻炎安全有效。 Objective To evaluate the efficacy and safety of azelastine hydrochloride tablet in allergic rhinitis in compare with loratadine. Methods A multicenter randomized doubl-blind and parallel-controlled clinical trail was conducted. Patients with mild to moderate allergic rhinitis received either azelastine hydrochloride tablet 1 mg twice daily or placebo tablet and loratadine tablet 10 mg each once daily for consecutive 14 days. Nasal symptom score, consisting of sneezing, runny nose, itchy nose, nasal congestion and nasal cavity condition scores was recored before, during and after the treatment. Results The total effective rate was 87.93% for azelastine group and 82.54% for loratadine group, and the adverse event rate was 8.62% and 14.06%, respectively. There was no statistical significant between the two groups. Conclusion Azelastine hydrochloride tablet was effective and safe for the treatment of allergic rhinitis.
出处 《中国临床药理学杂志》 CAS CSCD 北大核心 2004年第2期88-91,共4页 The Chinese Journal of Clinical Pharmacology
关键词 盐酸氮zhuó斯汀 氯雷他定 随机对照 治疗 变应性鼻炎 临床试验 azelastine hydrochlonde loratadine allergic rhinitis
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参考文献8

  • 1Chand N,Pillar J,Nolan K,et al.Inhibition of allergic and nonallerbic leukotriene C4 formation and histamine secretion by azelastine: implication for its mechanism of action[].International Archives of Allergy and Immunology.1989
  • 2Hamasaki Y,Shafigeh M,Yamamoto S,et al.Inhibition of leukotriene synthesis by azelastine[].Ann Allergy Asthma Immunol.1996
  • 3Lieberman PL,Settipane RA.Azelastine nasal spray: a review of pharmacology and clinical efficacy in allergic and nonallergic rhinitis[].Allergy and Asthma Proceedings.2003
  • 4Berger WE,White MV.Efficacy of azelastine nasal spray in patients with an unsatisfactory response to loratadine[].Ann Allergy Asthma Immunol.2003
  • 5Chervinsky P,Grossman J,Freitag JJ.Duration of action of a single dose of azelastine in patients with chronicasthma[].Journal of Asthma.1995
  • 6Bedard PM,del Carpio J,Drouin MA,et al.Onset of action of loratadine and placebo and other efficacy variables inpatients with seasonal allergic rhinitis[].Clinical Therapeutics.1992
  • 7Dockhorn RJ,Bergner A,Connell JT,et al.Safety and efficacy of loratadine(Sch-29851) : a new non-sedating antihistamine in seasonal allergic rhinitis[].Annals of Allergy.1987
  • 8Yanai K,Okamura N,Tagawa M,et al.New findings in pharmacological effects in duced by antihistamines: from PET studies to knock-out mice[].Clinical and Experimental Allergy.

同被引文献18

  • 1张罗,韩德民,顾之燕.抗组胺药物 H1 受体拮抗剂的临床药理学(一):组胺、组胺受体和抗组胺药物[J].中国耳鼻咽喉头颈外科,2005,12(1):61-64. 被引量:33
  • 2中华医学会耳鼻咽喉科学分会.变应性鼻炎诊断标准及疗效评定标准[J].中华耳鼻咽喉科杂志,1998,33(3):134-134.
  • 3Dahl R, Nielsen LP, Kips J, et al. Intranasal .and inhaled fluticasone propionate for poUeninduced rhinitis and asthma [J]. Allergy, 2005, 60(7) : 875-881.
  • 4刘佳合,文昭明,沙莉,等.变应性鼻炎对哮喘的影响[M].北京:首都儿科研究所哮喘防治与教育中心,2001:95.
  • 5顾文燕 顾瑞金.变应性鼻炎的药物疗法.中华耳鼻咽喉科杂志,35(5):106-106.
  • 6中华医学会耳鼻咽喉科学会分会.变应性鼻炎诊断标准及疗效评定标准(1997年,中华耳鼻咽喉科杂志编辑委员会,海口)[J].中华耳鼻咽喉科杂志,1998,33(3):134-135.
  • 7附:变应性鼻炎诊断标准及疗效评定标准(1997年修订,海口)[J]中华耳鼻咽喉科杂志,1998(03).
  • 8Dahl R,Nielsen LP,Kips J,et al.Intranasal and inhaled fluticasone propionate fore polleninduced rhinitis and asthma. Allergy . 2005
  • 9Nielsen LP,Mygind N,Dahl R.Intranasal corticosteroids for allergic rhinitis superior relief. Drugs . 2001
  • 10Mygird N,Nieson LP,Hoffmann HJ,et al.Mode of action intranasal corticosteroids. J Allergy Clin Immunolgy, 2001, 108(1) .

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