上海地区非甾体抗炎药不良反应回顾与分析

Primary analysis of retrospective investigation of non-steroidal anti-inflammatory drugs adverse drug reaction in Shanghai

目的 调查上海市长期使用非甾体抗炎药(NSAIDs)人群药物不良反应发生情况及相关参数。方法 用整群抽样,回顾性询问填表法,获取了1002例患者的基本情况、NSAID s使用情况、合并用药情况和药物不良反应(发生、治疗、预后)等情况。结果 调查显示,患者使用NSAIDs均在1年以上,药物不良反应发生率较高(66％),症状主要集中在胃肠道、皮疹、中枢症状,严重药物不良反应约7％,药物不良反应预后较好。结论 NSAID s药物不良反应受多种因素影响。

Objective To investigate the adverse drag reaction (ADR) and related parameters in non-steroidal anti-inflammatory drugs NSAIDS long-term used patients in Shanghai. Methods A cross-sectional survey was carried out and 1002 patients were recruited. A retrospective questionnaire was designed to get the information on personal information, usage of NSAIDs, concomitant therapy drug, adverse drug reaction, treatment and prognosis, et al. Results The ADR rate is about 66%, mainly are gastrointestinal symptoms, eruption and central nerve system symptoms. Severe ADR rate was 7%. Conclusion The ADR of NSAIDs is affected by many factors.