胸腺肽对白癜风患者疗效及对其免疫球蛋白的影响

Clinical trial on thymus reptide in the treatment of vitiligo and its effect on the immunoglobulin

目的 观察胸腺肽对白癜风患者疗效及对免疫球蛋白的影响。方法 用特定蛋白分析仪检测50例白癜风患者血清IgA、IgG、IgM和43例患者的C3、C4水平,并与20例健康人做对照;用胸腺肽治疗,并与常规疗法做对照。其中,试验组32例治疗前后均检测IgA、IgG、IgM,26例检测C3、c4。结果试验组总有效率为78.00％,对照组为30.30％,两组比较有显著性差异(P<0.01)。试验组与健康对照组比较,试验组c3、C4明显降低(P<0.01)。经胸腺肽治疗后,与治疗前比较,试验组IgA、IgM、IgG、c3、C4均无显著性差异。结论 白癜风患者体液免疫存在异常,胸腺肽对免疫球蛋白影响较小,其治疗白癜风获得较好疗效。

Objective To observe the effect of thymus peptide on the immunoglobulin in patients with vitiligo and the effect of treatment with thymus peptide. Methods The serum levels of immunoglobulin IgA, IgM, IgG of 50 patients and C3, C4 of 43 patients with vitiligo were determined by protein analyzer.The patients were treated with thymus peptide,and compared with routine treatment.The serum levels of immunoglobulin IgA, IgM, IgG 32 patients and C3, C4 26 patients with vitiligo in trial group were determined before and after the treatment. Results Effective rate of trial group and control group were 78.00% and 30.30%(P<0.01).Decrease of C3, C4 were found in trial group compared with the healthy group(P<0.01). After the treatment with thymus peptide, the levels of IgA, IgM, IgG and C3, C4 were no remarkable changes. Conclusion These results revealed that humoral immunity was impatived in vitiligo patients.The humoral immunity played an important role in pathogenesis of vitiligo. The vitiligo patients treated with thymus peptide could get some better effects.