摘要
氰乙酸甲酯经缩合、加成、环化、氨解、Hoffman重排、拆分制得抗惊厥药物普瑞巴林,总收率16.1%。
The anticonvulsant pregabalin was synthesized from methyl cyanoacetate via condensation, addition,cyclization, aminolysis,Hoffman rearrangement and followed by resolution with (S)-mandelic acid in an overall yield of16.1%.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2004年第4期195-196,共2页
Chinese Journal of Pharmaceuticals
关键词
普瑞巴林
抗惊厥药物
合成
拆分
pregabalin
anticonvulsant
synthesis
resolution
