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咪唑乙酸盐酸盐的制备 被引量：3

Preparation of Imidazol-1-acetic Acid Hydrochloride
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摘要 Imidazol-1-acetic acid hydrochloride was prepared from phase transfer catalytic N-alkylation ofimidazole with ethyl chloroacetate followed by hydrolysis with an overall yield of 36%. Imidazol-1-acetic acid hydrochloride was prepared from phase transfer catalytic N-alkylation ofimidazole with ethyl chloroacetate followed by hydrolysis with an overall yield of 36%.
作者 蒋晔 张晓青 徐智儒
机构地区 河北医科大学药学院
出处 《中国医药工业杂志》 CAS CSCD 北大核心 2004年第4期204-205,共2页 Chinese Journal of Pharmaceuticals
关键词 咪唑乙酸盐酸盐 制备 唑来膦酸 中间体 imidazol-1-acetic acid hydrochloride intermediate preparation
分类号 TQ460.4 [化学工程—制药化工]
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参考文献2

  • 1[1]Cheer SM, Noble S. Zoledronic acid[J]. Drugs, 2001, 61 (6):799-805.
  • 2[2]Easson APT, Pyman FL. A general method for the preparation of 1-substituted glyoxalines from acetalylthiocarbimide and primary amines[J]. J Chem Soc, 1932, 1806-1812.

同被引文献42

  • 1王洪勇,罗世能,刘晓亚,谢敏浩,何拥军.唑来膦酸的合成方法改进[J].江南大学学报（自然科学版）,2004,3(6):611-613. 被引量：5
  • 2蒋晔,张晓青,徐智儒.唑来膦酸的合成[J].华西药学杂志,2005,20(1):29-30. 被引量：8
  • 3王磊,孙兴华.用KOH/Al_2O_3合成N-烷基咪唑[J].应用化学,1993,10(4):84-85. 被引量：15
  • 4陈宝泉,李彩文,雷英杰,欧阳杰.2-(1-咪唑基)-乙酸的合成工艺改进[J].精细石油化工,2007,24(2):16-18. 被引量：5
  • 5Perry C M, Figgitt D P. Zoledronic acid:a review of its use in patients with advanced cancer [J]. Drugs,2004,64(11):1197-1211.
  • 6Aronhime, Judith, Lifshitz L, et al. Zoledronic acid crystal forms, zoledronate sodium salt crystal forms, amorphous zoledronate sodium salt, and processes for their preparation [P]. US: 7,435,827.
  • 7Zardin P C.Anti-tumour activity of zoledronic acid[J].Cancer Treatment Reviews,2005,31:S1-S8.
  • 8Saag K,Lindsay R,Krlegman A.A single zoledronic acid infusion reduces bone resorption markers more rapidly than weekly oral alendronate in postmenopausal women with low bone mineral density[J].Bone,2007,40:1238-1243.
  • 9Inter M C,Holen Coleman R E.Exploring the anti-tumour activity of bisphosphonates in early breast cancer[J].Cancer Treatment Reviews,2008,34:453-475.
  • 10Green J R.Zoledronic acid:Pharmacologic profile of a potent bisphosphonate[J].Journal of Organometallic Chemistry,2005,690:2439-2448.

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中国医药工业杂志
2004年 第4期

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