雷尼替丁、兰索拉唑和氢氧化镁铝抗实验性胃溃疡的比较研究

Study of ranitidine,lansoprazole and magaldrate on experinental gastric ulceration

目的 :比较雷尼替丁、兰索拉唑和氢氧化镁铝抗 3种实验性胃溃疡模型的作用。方法 :采用 3种实验性胃溃疡模型 :小鼠水浸应激性胃溃疡、大鼠幽门结扎型胃溃疡、大鼠乙酸烧灼型胃溃疡 ,以溃疡抑制率来比较三药的治疗效果。结果 :3种模型中兰索拉唑有明显的抑制溃疡形成的作用 (P <0 .0 5 ) ,溃疡指数是最低的 ,溃疡抑制率也均高于其他两药。结论 :兰索拉唑对于实验性胃溃疡的作用优于氢氧化镁铝。

Objective:Study and compare of ranitidine,lansoprazole and magaldrate on experinental gastric ulceration.Methods:Using the gastric ulcer model induced by restraint water-immersion stress in mice,pylorus-ligature in rats,acetic acid-burning in rats on gastric ulceration.Results:Pretreatment with lansoprazole significantly inhibited the formation of gastric ulcer in the models.The ulcer index was the smallest,the inhibitory efficiency was the higher than the others.Conclusion:The effect of lansoprazole on experinental gastric ulcer was better than magaldrate and ranitidine.