妥泰治疗癫癎的临床观察

CLINICAL OBSERVATION OF TREATING THE EPILEPSY WITH TOPIRAMATE

目的 :观察妥泰 (托吡酯 topiramate,TPM)治疗癫疒间 的效果、剂量及安全性。方法 :初始剂量成人 2 5mg/d,儿童 1 2 .5 mg/d,观察并记录癫疒间 发作次数。症状控制者不再加药。症状控制减少或不能控制继续加量。最高剂量 3 5 0 mg/d,最低剂量 5 0 mg/d。先观察 3 mo内结果 ,随后观察 48wk癫疒间 控制结果 ,记录发作次数 ,副反应及出现时间。结果 :3 5例病人完全控制 3 mo为 71 .43 % ,6mo为 76% ;症状基本控制 3 mo为 1 7.1 4% ,6mo为 2 0 % ;改善不明显和无效 3 mo为 1 7.1 4% ,6mo为 2 0 % ;副反应发生率 68% ,多数症状轻微 ,对症处理后好转 ,严重者占少数。结论 :TPM治疗癫疒间 疗效明显 ,较为安全 。

Objective: A clinical trial was conducted to observe the effect,dosage and security of topiramate (TPM) therapy for epilepsy. Methods: The starting doses of TPM were 25 mg/d for adult and 12.5 mg/d for child. We observed and recorded the times of seizures for three months. Keeping the dose for the patients that symptom was controlled,increasing the dose for the patients that symptom was not controlled or controlled was reduction, The maximum doses were 350 mg/d, the minimum doses were 50 mg/d. Thereafter we followed 48 weeks, and recorded the frequency of seizures, side effect and arose time of that. Results: 35 patients entered the study. Symptom controlled rate was 71.43% after three months, after six months was 76%. Symptom mostly controlled rate was 17.14% after three months, after six months was 20%. Rate of ineffective or indistinctive effect was 17.14% after three months, after six months was 20%. Side effect rate was 68% and mostly were slight, all patients were improve after treated, and few had serious side effect. Conclusion: TPM was effective and safe, dosage should be individuation.