输注血浆冷沉淀后血清调理作用对小鼠腹腔巨噬细胞吞噬功能的影响

The Serum Opsonic Effect on Normal Murine Macrophage Phagocytosis after Cryoprecipitate Infusion: Experimental and Clinical Studies

为探讨血浆冷沉淀(简称:冷沉淀)对创伤和感染的治疗作用,进行了输注冷沉淀对巨噬细胞吞噬功能影响的研究,结果证实:输注后血中纤维结合蛋白(Fn)水平及其活性较输前均有明显升高,巨噬细胞吞噬功能显著增强,患者病情得到改善。结果提示:输注富含Fn的冷淀为治疗严重创伤和感染病例,为预防多器官功能衰竭提供了一个新的途径。

For the purpose of exploring the effect of treatment of cryoprecipitate infusion on trauma and septic surgical patients, the serum opsonic functions on macrophages were investigated following missile wound of the abdomen in dogs and patients suffered from severe trauma and infection. The results indicated that after receiving cryoprecipitate infusion, Fn level and biological activity in plasma increased obviously, and the sera remarkablly intensified the normal murine macrophage phagocytosis. Clinical condition in patients were markedly improved by the treatment of cryoprecipitate infusion. It is suggested that Fnrich human plasma cryoprecipitate infusion may offer a new approach to the treatment in severe traumatic and septic surgical patients and to the prevention of MOF.