骨组织工程研究进展

Advances in tissue engineering of bone

骨组织工程是目前公认的最有可能在临床取得实际效益的研究领域之一。在种子细胞方面,干细胞向成骨细胞的诱导分化、种子细胞的体外大规模扩增等是组织工程骨构建和临床应用的首要环节和基本要素。生物材料研究的热点在于新型仿生化、智能化生物材料的制备和应用。在组织工程骨的构建方面,血管、神经化组织工程骨的同步构建与应用研究是骨组织工程由基础向临床应用的关键性环节。在上述研究的基础上,骨组织工程已得到初步临床应用,在取得较好疗效的同时,又为骨组织工程的基础研究提出了许多新的课题和研究方向。本文从种子细胞、生物材料、组织构建及其临床应用等方面对近年来骨组织工程的研究现状进行综述,并对骨组织工程研究现存的问题进行分析,提出骨组织工程进一步发展的若干策略。

Bone tissue engineering is one of the most promising fields that can bring about clinical benefits in the near future. Induction and differe ntiation of stem cells and proliferation of cells are the first and essential st ep in seeding cell study which can lead to the construction of tissue engineered bone. In biomaterial study, preparation and application of the new aptitudinal biomaterials are the focuses in recent research. Vascular and nerval constructio n of the tissue engineered bone is another very important step. Recently bone ti ssue engineering has been used to treat the clinical bone defects and get the fa vorable results. This paper introduces in general the recent progress made in th e research of bone tissue engineering on seeding cell, biomaterials, tissue-eng ineered bone construction and clinical application of the bone tissue engineerin g. It also analyzes the existing problems in the research and thus put forward s ome strategies for the future development in China.