骨折并发感染患者肠道通透性研究

Intestinal permeability of infected fracture patients

目的测定骨折并发感染患者肠道通透性的改变,探讨骨折并发感染患者肠粘膜屏障功能的改变。方法健康志愿者、骨折并发感染患者各15名,口服乳果糖、甘露醇液后采集6h尿样,尿样和乳果糖、甘露醇的标准样经肟化处理后通过气相色谱分析仪进行检测分析。结果甘露醇峰、乳果糖峰出峰时间稳定,峰面积随含量增加而增加,并且呈线性相关;骨折并发感染患者与健康志愿者尿样中的乳果糖含量和乳果糖/甘露醇存在显著差异(P<0.05),而甘露醇含量两组无显著差异(P>0.05)。结论骨折并发感染患者肠粘膜通透性增加,存在肠粘膜屏障功能损害。

Objective To assess the intestinal barrier function of the infec te d fracture patients by studying the intestinal permeability. Methods 16 infected fracture patients and 15 healthy volunteers were enrolled. After ingestion of m annitol and lactulose in de-ionized water,a 6-h urine collection was used to analyze mannitol and lactulose concentrations by gas-liquid chromatography. Res ults The lactulose concentration and lactulose/ mannitol (L/M) ratio in the infe cted fracture patients increased and were statistically different from those in the healthy volunteers (P< 0.05). Conclusion The intestinal permeability of the infected fracture patients will increase so that the patients may have intestina l barrier dysfunction.