利培酮与氯氮平对首发精神分裂症患者社会功能的影响

Effect of risperdal and clozapine on the social function in patients with first-epispde schizophrenia

目的:探讨利培酮与氯氮平对首发精神分裂症患者社会功能的影响。方法:采用社会功能缺陷筛选量表(SDSS)对106例(脱落23例,83例完成研究)首发精神分裂症患者的社会功能进行评定,并比较利培酮(n=43)与氯氮平(n=40)治疗首发精神分裂症患者对其社会功能的影响。结果:利培酮治疗的首发精神分裂症患者家庭内活动过少(3%,7/43)、家庭职能(3%,7/43)、个人生活自理缺陷发生率(5%,3/43)和SDSS分均显著低于氯氮平治疗的患者(χ2=4.847,4.847,4.295;t=0.718-2.684;P均<0.05);利培酮治疗的患者对外界的兴趣和关心SDSS分显著低于氯氮平治疗的患者(0.12±0.39和0.33±0.66,t=1.771,P<0.05)。结论:利培酮对首发精神分裂症患者社会功能的影响优于氯氮平。

AIM:To explore the effect of risperdal and clozapine on the social function in patients with first episode schizophrenia. METHODS:Social function of 106 patients with first episode schizophrenia(23 stopped and 83 finished the study) was evaluated with Social Disability Screening Schedule(SDSS).And the effects of risperdal(n=43)and clozapine(n=40)on the social ability in patients with first episode schizophrenia were compared. RESULTS:The family activity(3%,7/43), family function(3%,7/43),the rate of personal care disability(5%,3/43) and the score of the SDSS of patients treated with risperdal were significantly lower than those treated with clozapine(χ2=4.847,4.847,4.295;t=0.718-2.684; P< 0.05). The interest in environment and score of SDSS of the patients treated with risperdal were significantly lower than those treated with clozapine(0.12±0.39,0.33±0.66, t=1.771,P< 0.05).