早期营养干预对宫内生长迟缓大鼠小肠发育及体格生长的影响(英文)

Effects of Early Nutrition After Birth on the Development of Small Intestine and Body Growth in Rats with Intrauterine Growth Retardation

目的 了解出生后早期营养干预对宫内生长迟缓 (IUGR)大鼠体格、小肠发育的影响。方法 生后 4周内每周分别测量正常大鼠正常饮食组 (CC) ,IUGR正常饮食组 (IC)、低蛋白饮食组 (IL)及高蛋白饮食组(IH)大鼠体重、身长。并于出生时及第 3,4周测量其小肠长度、重量及肠粘膜双糖酶 (乳糖酶、麦芽糖酶、蔗糖酶 )活力。结果 ①IUGR鼠出生时体重、身长、小肠长度及重量均显著小于正常鼠 (P <0 .0 5 ) ;乳糖酶、麦芽糖酶活力高于正常组 (P <0 .0 5 )。②IL组身长、体重、小肠重量及长度生后初 4周均落后于CC ,IC和IH组 (P <0 .0 5 ) ;IH组体格、小肠追赶生长迅速 ,4周时体重与CC组比较差异无显著性 (P >0 .0 5 )。③ 3周时IL ,IH组乳糖酶活力高于CC组 (P <0 .0 5 ) ;4周时IL组蔗糖酶活力小于CC组 (P <0 .0 5 )。结论 生后早期营养干预对IU GR大鼠早期体格追赶生长、小肠发育有重要的影响。

Objective To study the effect of early nutrition on the development of physique and small intestine in rats with intrauterine growth retardation (IUGR). Methods Eight normal pubs fed with normal protein diet (20%) were used as normal controls. The IUGR pups were assigned into normal protein diet group (IC group), low protein diet group (IL group) and high protein diet group (IH group). On the 1st, 21st and 28th day after birth respectively, the weight and length of small intestine (SI), the body weight and length, and the activities of disaccharidase were measured. Results The body weight and length, weight and length of SI in rats with IUGR at birth were all significantly lower than those in normal rats (P< 0.05 ). Body length, body weight, length and weight of SI in IL group were all lower than those in IC, IH and normal control groups in the first 4 weeks after birth. The physique and small intestine in IH group caught up growth quickly, the body weight in the 4th week reached the normal value. In the third week, the lactase activity in IL and IH groups were higher than that in normal control group (P< 0.05 ). In the 4th week, the sucrase activity in IL group was lower than that in normal control (P< 0.05 ). Conclusions Early nutrition after birth has an important effect on the development of physique and SI in rats with IUGR.