大肠癌中FAK的表达与生物学行为关系的研究

Expression of Focal Adhesion Kinase in Colorectal Carcinomas and its Biological Significance

目的:研究粘着斑激酶(FAK)在大肠癌及癌旁组织中的表达及与肿瘤细胞分化、浸润、转移等生物学行为的关系。方法:应用免疫组织化学LSAB法检测60例大肠癌及癌旁组织石蜡标本中FAK蛋白的表达水平。结果:FAK在癌组织中的表达明显高于癌旁组织,低分化癌组织较高分化、中分化组织中FAK的表达高,有淋巴结转移的组织较无转移的组织表达高,浸润程度越深表达越高。结论:FAK可能是一种转化相关酶又是一种演变相关酶。FAK的表达量可作为肿瘤发生、发展过程中一种较有价值的病理指标。

Objective:To study the correlation between FAK expression in colorectal car-cinoma and noncancerous tissue and clinicopathological data including tumor differentiation,infil-trating and lymph node metastasis.Methods:Expression of FAK was examined in60colorectal carcinomas by immunohistochemical technique.Results:The staining of FAK was stronger in col-orectal carcinomas than in the epithelias of noncancerous areas and was higher in low differentia-tion cancer cells than in well differentiation ones.The cancers with lymph node metastasis had more FAK expression than the cancers without lymph node metastasis and the deeper extent of infiltrating,the higher FAK expression.Conclusions:The FAK might be not only a transformation related enzyme but also a progression related enzyme.The level of FAK expression might be a valuable marker for the carcinogenesis and progression of the carcinoma.