血管内皮功能与体脂含量、分布及胰岛素抵抗的关系

THE RELATIONSHIP BETWEEN ADIPOSE TISSUE DEPOSITION AND DISTRIBUTION AND INSULIN RESISTANCE WITH ENDOTHELIAL FUNCTION IN MIDDLE-AGED SUBJECTS

探讨体脂含量、分布和胰岛素抵抗 (IR)对血管内皮功能的影响。 5 2 7例年龄 35～ 5 5岁的石家庄市居民 ,经健康检查各项临床和实验室指标未见异常。用高分辨率超声仪测定肱动脉血流介导的内皮依赖性血管舒张 (EDD) ,并测定体重指数 (BMI)、腰围 (W)、腰臀比 (WHR)和IR指数 (HOMA IR)。结果显示 ,内皮功能异常者的BMI、W、WHR和HOMA IR均较内皮功能正常者显著增加 ,BMI的升高主要表现在女性肥胖者 ,而W和WHR的升高则仅在各组男性中有显著差异。HOMA IR在超重和肥胖组男性及各组女性中均有显著差异。相关分析表明 ,BMI、WHR和HOMA IR是影响EDD的主要因素 ,但存在性别差异。W和EDD在男女性中均是参与IR的因素。

To investigate the relationship between adipose tissue deposition and distribution and insulin resistance(IR)with endothelial function, the flow mediated endothelium dependent dilatation (EDD), body mass index (BMI), waist circumference (W), waist hip ratio (WHR) and IR index (HOMA IR) were measured, and the relationship of adipose tissue deposition and IR with endothelial dysfunction were analyzed in 527 subjects aged 35～55years without abnormal clinical and laboratory parameters. The results showed that BMI, W, WHR, and HOMA IR in subjects with impaired endothelial function were higher than those with normal one, a high BMI was mainly found in females with obesity, large W and WHR were mainly found in males all groups, and abnormal HOMA IR was found in overweight and obese males and also females in all subgroups. Multiple regression analysis indicated that BMI, WHR and HOMA IR were major factors affecting EDD, though there were gender differences. Both W and EDD were factors involved in IR in both genders. In conclusion, there are close correlations between endothelial function and adipose tissue deposition and distribution and IR