不同正加速度暴露下人体尿α_1-微球蛋白测定的意义

THE SIGNIFICANCE OF URINARY α_1-MICROGLOBULIN AFTER EXPOSURE TO ACCELERATION OF DIFFERENT SPEED

目的 观察不同正加速度 (+Gz)暴露下人体尿α1 微球蛋白 (α1 M)的变化规律。方法 6名健康男性受试者 ,分别进行抗荷裤配抗荷调压器的抗荷效果试验、抗荷正压呼吸的抗荷效果试验、抗荷裤配抗荷调压器 +PBG +抗荷动作的抗荷效果试验 3组 +Gz暴露。留取每组 +Gz暴露前、+Gz暴露后 30min、+Gz暴露后 2 4h的尿液各 5ml。结果 ①受试者在采用抗荷装备后 ,所达到的 +Gz耐力分别为 6 2 5± 0 5 2G、8 17± 0 2 6G、9 0 0G ;②与 +Gz暴露前相比 ,+Gz暴露后 30min尿α1 M浓度升高 ,差异有显著性意义(P <0 0 5或P<0 0 1) ;③ +Gz暴露后 2 4h与 +Gz暴露后 30min相比 ,尿中α1 M浓度下降 ,差异有显著性意义 (P <0 0 5或P <0 0 1) ,能恢复到基本接近于 +Gz暴露前水平。结论 +Gz暴露所致人体尿中α1 M浓度升高 。

Objective To observe the changes in contents of α 1 Microglobulin (α 1 M) in urine after exposure to acceleration of different speeds(+Gz) in order to provide scientific indications for efficient protection for pilots under high +Gz acceleration and efficient flight health service support. Methods Six healthy men were subjected to the following experiments: ①pressurized anti G suit (KH X); ②pressure breathing for +Gz (PBG); ③pressurized anti G suit and PBG and AGSM (up to +9Gz for 10 s). Urine samples were collected before, immediately after, 30 minutes and 24 hour after the exposures for the determination of α 1 microgolbulin (α 1 M). Results It was found that ①The G tolerances of subjects under 3 conditions were (6 25±0 52) G/10s, (8 17±0 26) G/10s, 6 5G/30s, and 9 00 G/10s, respectively. ②30 minutes after each series of exposure, the contents of α 1 M in urine samples were increased ( P <0 05 or P <0 01). The higher the +Gz value, the higher the increase in the content, and it was most evident ( P <0 01) during the fourth series of exposure (up to +9Gz/10 s). ③24 hours after the exposure, α 1 M was reduced significantly ( P <0 05 or P <0 01), approximating the pre exposure level. The results showed that high +Gz stress or repeated +Gz exposures could lead to significant increase in urinary α 1 M content, indicating renal injury. Conclusions The α 1 M could be used as an early diagnostic indicator of renal injury.