特异性抗原密度联合前列腺穿刺活检诊断前列腺癌的价值

Efficacy for clinical diagnosis of PSAT and prostatic biopsy

目的 :评价前列腺移行带特异性抗原密度 (PSAT)与前列腺穿刺活检联合检测在前列腺癌 (PCa)诊断中的价值。方法 :对 4 9例血清PSA >10 μg/L患者行前列腺穿刺活检后 ,部分给予重复穿刺及手术治疗 ,综合比较PSAT。结果 :4 9例中 ,前列腺活检病理检查诊断为PCa 2 4例 (4 8.98% ) ,良性前列腺增生 (BPH) 2 5例 (5 1.0 2 % ) ,其PSAT平均值分别为 (0 .6 1± 0 .11)、(0 .38± 0 .13) μg/L ,两者相比差别有统计学意义 (P <0 .0 1) ;后者行手术治疗后病理检查诊断为PCa 6例 (2 4 % ) ,BPH 19例 (76 % ) ,其PSAT平均值分别为 (0 .4 0± 0 .11)、(0 .32± 0 .0 7) μg/L ,两者相比差别有统计学意义 (P <0 .0 5 )。结论 :PSAT对PCa ,特别是早中期PCa的诊断 ,比前列腺穿刺活检更为敏感 ,二者联合检测对临床诊治有重要的价值和意义。

Objective:To evaluate the diagnostic efficacy of the prostate specific antigen density of the transitional zone(PSAT) and the prostatic biopsy for prostatic cancer.Method:The diagnostic value of PSAT for 73 cases with a serum PSA>10 ng/ml underwent prostate biopsy were evaluated.Result:In the 73 cases, 48 were prostate cancer(PCa) and 25 benign prostatic hyperplasia(BPH). The mean value of PSAT were 0.67± 0.15 and 0.38± 0.14, respectively, the difference of PSAT had magnificant statistical significance (P< 0.01). The histopathology after operations indicated that there were 6 Pca in 25 BPH cases, The mean value of PSAT were 0.40± 0.12 (6 Pca) and 0.31± 0.07 (19 BPH), the difference between them was statistically significant (P< 0.05).Conclusion:PSAT is more sensitive than the prostatic biopsy for the diagnosis of PCa, especially for the screening diagnosis. The combination of the PSAT and the prostatic biopsy is valuable for the clinical diagnosis and treatment of Pca.