获得性肾囊肿危险因素的配对病例对照研究

A matched pair case control study on the risk factors of acquired renal cystic

目的 :探讨影响获得性肾囊肿 (ARC)发病的危险因素。方法 :回顾性分析 5 3例ARC患者临床资料 ,进行 1∶1配对病例对照研究 ,并建立回归模型分析其危险因素 ,在α =0 .0 5水平确定其危险因素。结果 :经过单因素条件回归、多因素条件Logistic回归、逐步条件回归分析 ,结果显示肌酐清除率 (Ccr)水平 (OR =0 .4 98,P =0 .0 112 ,β =- 0 .6 976 2 )和年龄 (OR =2 .0 93,P =0 .0 2 71,β =0 .7385 2 )与ARC有显著性 (P <0 .0 5 )关联。结论 :Ccr水平和年龄是ARC的危险因素 ,慢性肾脏疾病患者随着Ccr下降和 (或 )年龄增加 ,ARC发病率呈上升趋势。

Objective:To observe the risk factors of ARC in chronic renal disease patients.Method:A respective matched pair case control study was conducted to identify the risk factors of ARC. 53 patients with ARC were matched for basic renal disease to controls. Univariable analysis was performed to select variables, multiple conditional logistic regression and stepwise regression was used to estimate odds ratios.Result:As a result of stepwise regression, age (OR= 2.093) and Ccr (OR= 0.498) were powerfully associated with ARC.Conclusion:Age and Ccr were the possible risk factors of ARC. With the increase of age or the decrease of Ccr, ARC were highly prevalent among chronic renal disease patients.