CK20对大肠癌的诊断价值探讨

Research on diagnosing colorectal carcinoma by CK20 with the RT-PCR

目的 探讨CK2 0对大肠癌的诊断价值。方法 采用RT PCR定性检测外周静脉血中的CK2 0。结果 6 2例恶性肿瘤中 ,CK2 0阳性率 70 .96 % ,35例非恶性肿瘤中CK2 0阳性率 1 7.1 4 % (χ2 =2 6 .8735 ,P <0 .0 1 )。 5 3例大肠癌中CK2 0阳性 4 1例 ,4 5例非大肠癌中CK2 0阳性 9例 ,诊断性试验评价 ,敏感度 74 .4 2 % ;特异度 80 % ,准确度 78% ,阳性拟然比 3.72 ,阴性拟然比 0 .2 83。结论 CK2 0可能是恶性肿瘤的标志物 ,CK2 0对诊断大肠癌有一定价值 ,但作为一项特异性诊断大肠癌的指标还须进一步改进和探索。

Objective To explore the diagnostic value of CK20 in the colorectal carcinoma.Methods CK20 in the peripheral blood was investigated by RT PCR.Results were analyzed by the ch square test and the diagnostic test.Results CK20 positive rate was 70.96% in the 62 case malignant tumor,CK20 negative rate was 17.14% in the 35 case benign tumor (χ 2 = 26.873 5, P < 0.01 ).CK20 positive case were 41 in the 53 case colorectal carcinoma,CK20 negative case were 9 in the 45 case non colorectal carcinoma.Diagnostic test evaluate that the sensitivity was 74.42%,the specificity was 80%,the accuracy was 78%,positive likelihood ratio was 3.72,negative likelihood ratio was 0.283.Conclusion CK20 may be the malignant tumor marker and may be diagnostic value of the colorectal carcinoma.It should be improved and researched to use CK20 as a special diagnosis criteria in the colorectal carcinoma.