骨痛宁搽剂对去势雌性大鼠股骨生物力学的影响

Effects of gutongning chaji on the biomechanics of femur in ovariectomized female rats

目的:观察骨痛宁搽剂对骨质疏松(osteoporosis,OP)所致骨生物力学的影响。方法:通过切除大白鼠卵巢建立大鼠雌激素缺乏OP模型,分别给予骨痛宁擦剂(TN组)、骨质增生一贴灵(T组)及骨友灵擦剂(Y组)于大鼠大腿外用,并与正常大鼠(N组)、假手术(S组)及模型(OP组)对照,分别测量股骨抗弯模量、比例极限抗弯力、破坏弯矩、破坏能量吸收。结果:T,Y及OP组股骨抗弯模量、破坏弯矩、破坏吸收能量均低于S,N及TN组;TN组比例极限抗弯力高于Y及OP组。TN组生物力学与S及N组无差异。结论:骨痛宁擦剂可改善去势大鼠雌激素缺乏导致的力学改变,提高其生物力学强度。

AIM:To observe the effect of gutongning chaji on the biomechanical properties of the femur induced by osteoporosis(OP). METHODS:The OP models of white rats lacking estrogen were established by ovari ectomy.The rats were divided into gutongning chaji group(treated with gutongning chaji), guzhizengsheng yitieling group(treated with guzhizengsheng yitieling),g uyouling caji group(treated with guyouling caji)(the drugs for the groups above were embrocated on the lateral thigh of rats),normal control group,sham operatio n group,and OP group.The anti-bending modulus,failure bending moment,limits of proportionality of anti-bending force and failure energy-absorbing were measur ed 6 weeks after treatment. RESULTS:The anti-bending modulus,failure bending moment and failure energy-a bsorbing of guzhizengsheng yitielin,guyouling caji and OP groups were lower than those of sham operation group, normal control group and gutongning chaji group. The limits of proportionality of anti-bending force of gutongning chaji group w as higher than guyouling caji and OP groups.There were no differences in biomech anical properties among gutongning chaji,sham operation and normal control group s. CONCLUSION:Gutongning chaji can improve the biomechanical changes because of l ack of estrogen in the ovariectomized rats with osteoporosis,and promote the bio mechanical strength.