米索前列醇预防产后出血90例分析

Analysis of 90 cases on reduction of postpartum bleeding by misoprostol

目的 观察米索前列醇用于预防因宫缩乏力引起产后出血的效果。方法 选择 90例阴道分娩者 ,随机分为米索前列醇组、米索前列醇 +缩宫素组及缩宫素组。米索前列醇组 3 0例 ,于胎儿娩出后口服米索前列醇 40 0 μg。米索前列醇 +缩宫素组 3 0例 ,胎儿娩出后口服米索前列醇 40 0 μg ,同时肌内注射缩宫素10IU。缩宫素组 3 0例 ,胎儿娩出后肌注缩宫素 10IU ,同时静脉滴注缩宫素 2 0IU。以上各组观察产时及产后 2h阴道出血量。结果 产时及产后 2h平均出血量 ,米索前列醇组 14 2± 56 0ml,米索前列醇 +缩宫素组13 8± 55 4ml ,缩宫素组 2 75± 64 7ml。米索前列醇组与缩宫素组之间差异有显著意义 (P <0 0 1) ,米索前列醇组与米索前列醇 +缩宫素组相比较 ,差异无显著意义 (P >0 0 5)。结论 米索前列醇促进子宫收缩作用强于缩宫素 。

Objective To observe the effe ct of misoprostol on reduction of postpartum bleeding.Methods Nin ety primiparas were divided randomly into three groups:misoprostol group(n=30),400μg misoprostol was given orally after delivery of baby,misp rostol and oxytocin group(n=30),400μg misoprostol was given or ally and 10 IU oxytocin was injected into muscle after delivery,oxytocin group( n=30),10 IU oxytocin was injected into muscle and 20 IU intrave nous injection immediately after delivery.The amount of bleeding within 2 hours after delivery was measured.Results The mean amount of bleeding in misoprostol group was 142±56.0ml,in misoprostol and oxytocin group was 138 ±55.4ml,oxytocin group was 275±64.7ml,respectively.The difference was signific ant(P<0.01) between misoprostol group and oxytocin group,there was no differences between misoprostol group and misoprostol plus oxytocin group (P>0.05).Conclusion Misoprostol is more effect ive in reduction of postpartum bleeding than that of oxytocin.