经肝动脉平阳霉素碘油乳剂介入治疗肝海绵状血管瘤

Transarterial embolization with pingyangmycin-lipiodol emulsion in the treatment of hepatic hemangioma

目的 :评价平阳霉素碘油乳剂肝动脉栓塞治疗肝海绵状血管瘤的临床疗效。方法 :对 2 1例肝海绵状血管瘤患者 ,经导管肝动脉内注入平阳霉素碘油乳剂 5～ 2 0ml ,然后用明胶海绵或聚乙烯醇 (PVA)颗粒适量栓塞肿瘤供血动脉。结果 :所有病例术前肝动脉造影均显示典型的肝海绵状血管瘤血管造影征象 :“爆米花样染色”、“早出晚归”的异常血管湖样改变。所有病例均成功实施了栓塞治疗 ,栓后肿瘤血供中断 ,瘤体缩小 ,临床症状减轻或消失。结论 :采用介入方法经导管注入平阳霉素碘油乳剂加适量明胶海绵或PVA颗粒治疗肝血管瘤 ,是一种微创、安全、简便可行且疗效显著的治疗方法。

Objective:To study the therapeutic effect of embolization with pingyangmycin-lipiodol emulsion (PLE) for hepatic cavernous hemangioma (HCH).Methods:21 patients with HCH were studied.In all cases,a mixture of pingyangmycin (PYM) (8～24mg) and lipiodol-ultrafluid (5～20ml) was administered via the catheter and followed by gelfoam particles.Results:The 'popcorn-like tumor stain' sign and 'early fill-in and persistant staining' sign of hepatic arterial angiography were observed in all cases before embolization.The collection of lipiodol in the tumor and occlusion of tumor vessels were proved by postembolization angiography.In all patients,symptoms relieved and tumor size decreased.Conclusion:Hepa- tic arterial embolization with PLE and gelfoam particles is an effective method for treatment of hepatic cavernous hemangioma.