培哚普利对老年心力衰竭患者血中可溶性细胞间黏附分子-1和细胞凋亡抑制因子的影响

Effects of perindopril on sICAM-1 and Fas/Apo-1 in peripheral blood of elderly patients with congestive heart failure

目的 观察培哚普利对老年慢性心力衰竭 (CHF)患者循环血中可溶性细胞间黏附分子 1(sICAM 1)和细胞凋亡抑制因子 (Fas Apo 1)水平的影响。方法 用酶联免疫方法检测 5 3例老年CHF患者治疗前后及 2 5例健康老年人血中sICAM 1和Fas Apo 1水平。结果 老年CHF患者sICAM 1和Fas Apo 1水平分别为 (6 0 2 .6 1± 14 8.5 8) μg Lvs(0 .2 7± 0 .0 8) μg L ,显著高于 2 5例健康老年人 (178.5 4± 31.0 1) μg Lvs (0 .12± 0 .0 4 ) μg L ,且随着心功能损害程度加重而升高 ,各组间比较差异有显著性意义。培哚普利组与治疗对照组治疗前后血中sICAM 1和Fas Apo 1浓度水平差异有显著性意义 ,培哚普利组较治疗对照组治疗后血中sICAM 1和Fas Apo 1下降明显。结论 外周血中sICAM 1和Fas Apo 1水平可反映老年CHF的程度 ;培哚普利可明显降低老年CHF患者血中sICAM 1和Fas Apo 1的水平 ,从而保护和改善心功能。

Objective To explore the effects of perindopril on circulating levels of soluble intercellular adhesion molecule-1(sICAM-1) and Fas/Apo-1 in elderly patients with congestive heart failure (CHF).Methods The levels of circulating sICAM-1 and Fas/Apo-1 were determined by enzyme-linked immunosorbent assay (ELISA) in 53 elderly CHF cases and 25 elderly healthy subjects as control.Results The levels of sICAM-1 and Fas/Apo-1 in all the 53 elderly CHF cases were much higher than those of the control subjects(602.61±148.58 μg/L vs 178.54±31.01 μg/L;0.27±0.08 μg/L vs 0.12±0.04 μg/L,respectively) and increased significantly in CHF cases with decreasing cardiac function. The levels of circulating sICAM-1 and Fas/Apo-1 significantly decreased after the treatment in both perindopril group and conventional treatment group.Compared with those in conventional treatment group, The levels of circulating sICAM-1 and Fas/Apo-1 were significantly lower in perindopril group.Conclusions The levels of circulating sICAM-1 and Fas/Apo-1 can reflect cardiac dysfunction degree.Perindopril may play an important role in protecting and improving cardiac function by decreasing levels of sICAM-1 and Fas/Apo-1 in peripheral blood of elderly patients with CHF.