阿苯达唑治疗泡球蚴病患者血清中Th1/Th2型细胞因子的变化及临床意义

Immunological marker indicating the curative effects of treatment in AE patients with albendazole

目的 为探讨泡球蚴病患者经阿苯达唑治疗后 ,机体免疫应答的状态和对病程转归影响。方法 35例泡球蚴病患者经阿苯达唑治疗 1 2月前后 ,血清中sIL - 2R ,IFN -γ ,IL - 4IL - 5 ,IL - 6 ,TNFα,及特异性IgG ,IgE抗体进行检测。 结果 在治疗 1 2月后 ,Th1型细胞因子sIL - 2R ,IFN -γ无改变 (P >0 0 5) ,Th2型细胞因子IL - 4显著性下降 (P <0 0 1 ) ,IL - 5在患者中检出率明显降低 (P <0 0 1 ) ,TNFα和IgE水平较治疗前显著性下降 (P <0 0 1 )。 结论 泡球蚴病患者治疗后 ,Th2型细胞因子反应减弱 。

Aim To explore immunological marker and the outcome of disease after pharmacological treatment in human AE with albendazole Methods 35 patients were treated with albendazole for 12 months total treatment Levels of soluble IL 2R,IFN γ,IL 4,IL 5,IL 6,TNFα and specific IgG,IgE antibody in sera were detected before and after therapy Results Th1 type cytokines IL 2R and IFN γ were not significant difference before and after treatment(P>0 05) Levels of IL 4 and IL 5 from Th 2 type cytokines,and TNFα,IgE were remarkable decreased after treatment(P<0 01) Levels of IL 6 and IgG antibody were not changed as compared with before treatment group(P>0 05) Conclusion Th 2 type cytokines response appeared weakness and Th 1 response got strong in AE patients who were treated with albendazole Th1 cell activation in protective immunity had certainly recovery