卵巢癌患者血浆组织因子途径抑制物变化的临床意义

Clinical Value of Tissue Factor Pathway Inhibitor in Ovarian Cancer

目的 :研究血浆组织因子途径抑制物 (TFPI)抗原含量及活性对卵巢癌患者的临床意义。方法 :应用双抗体夹心酶联免疫吸附法及发色底物法对 38例卵巢癌患者血浆TFPI抗原含量及活性进行测定。结果 :卵巢癌患者血浆TFPI抗原含量及活性明显增高 ,且晚期患者也较早期患者血浆TFPI抗原含量及活性明显增高。结论 :监测卵巢癌患者血浆TFPI抗原含量及活性有助于诊断及观察病情和判断预后。

Objective To study the clinical value of the quantities and the activity of tissue factor pathway inhibitor (TFPI) in ovarian cancer. Methods The quantities and activity of the TFPI were measured in 38 women with ovarian cancer by using an quantitative enzyme linked sandwich immunoassay(ELISA) and Substrate chromatography.Results The quantities and actitvity of TFPI increased significantly in malignant patients and they increased more significantly in the late stage of cancer compared with in the early stage.Conclusions Measuring of the quantities and actitvity of TFPI is beneficial to the diagnosis,diseases activity evaluation and prognosis.