期刊文献+

NF-κB与Hp感染及胃癌关系的研究进展 被引量:7

下载PDF
导出
摘要 NF-κB是一组分布和作用均十分广泛的转录因子,具有显著的促细胞生长及抗凋亡作用,与细胞恶性转化关系密切。近年来的研究发现,胃癌组织中NF-κB呈持续活化状态,在体外试验中,幽门螺杆菌(Hp)可诱导胃癌细胞株NF-κB持续激活。NF-κB通过调控各种靶基因转录,与胃癌的发生、发展及转移有关。
出处 《国外医学(遗传学分册)》 2004年第2期102-105,共4页 Foreign Medical Sciences(Section of Genetics )
  • 相关文献

参考文献24

  • 1Kim H, Lim JW, Kim KH, et al. Helicobacter pylori-induced expression of interleukin-8 and cyclooxygenase-2 in AGS gastric epithalial cells: mediation by nuclear factor-kappaB. Scand J Gastroenterol, 2001,36(7):706-716.
  • 2Reuning U, Wilhelm O, Nishiguchi T, et al. Inhibition of NF-kappaB-Rel A expression by antisense oligodeoxynucleotides suppresses synthesis of urokinase-type plasminogen activator (uPA) but not its inhibitor PAI-1. Nucleic Acids Res, 1995, 23: 3887-3893.
  • 3Maeda S, Yeshida H, Ogura K, et al. H. pylori activates NF-kappaB through a signaling pathway involving IkappaB kinases, NF-kappaBinducing kinase, TRAF2, and TRAF6 in gastric cancer cells. Gastroenterology, 2000,119( 1 ):97-108.
  • 4Sharma SA, Tummum MK, Blaser MT, et al. Activation of IL-8 Gene Expression by Helicobacter pylori Is Regulated by Transcription Factor Nuclear Factor-κB in Gastric Epithelial Cells.The Journal of Immunolngy, 1998,160(5):2401-2407.
  • 5Mori N, Wada A, Hirayama T, et al. Activation of intercellular adhesion molecule 1 expression by helicobacter pylori Is regulated by NF-κB in gastric epithelial cancer cells. Infect Immunity, 2000,68(4):1806-1814, 9019-9567.
  • 6Kanai M, Konda Y, Nakajima T, et al. TGF-alpha inhibits apoptosis of murine gastric pit cells through an NF-kappaB-dependent pathway. Gastroenterology 2001,121( 1 ):56-67.
  • 7Wang W, Abbruzzese JL, Evans DB, et al. The nuclear factor-kappaB RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells. Clin. Cancer Res, 1999,5:119-127.
  • 8Hla T, Neilsen KO. Human cyclooxyganase-2 cDNA. Proc Natl Acad Sci USA, 1992,89: 7384-7388.
  • 9Kim H, Lim JW, Seo JY, et al. Oxidant-sensitive transcriptionfactor and cyclooxygenase-2 by Helicobacter pylori stimulation in human gastric cancer cells. J Environ Pathol Toxicol Oncol, 2002,21 (2):121-129.
  • 10Seibert K, Masferrer J, Zhang Y, et al. Mediation of inflammation by COX-2. Agents Actions Suppl, 1995, 46: 41-50.

同被引文献51

引证文献7

二级引证文献19

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部