肿瘤坏死因子α及吡咯烷二硫代氨基甲酸酯诱导雄激素非依赖性前列腺癌细胞凋亡的观察
The experimental study in apoptosis of androgen independent prostate cancer cells indused by TNFα and PDTC
摘要
目的 探讨肿瘤坏死因子α(TNFα)与吡咯烷二硫代氨基甲酸酯 (PDTC)诱导雄激素非依赖性前列腺癌细胞的凋亡。方法 分别及联合应用TNFα、PDTC ,治疗雄激素非依赖性前列腺癌细胞株 (PC 3)所复制的SCID鼠荷瘤模型 ,随机分成 4组 ,每组 7只 ,观察瘤体变化并检测肿瘤细胞凋亡情况。结果 TNFα及PDTC均可抑制肿瘤生长 ,TNFα与PDTC联合治疗可显著缩小瘤体 ,其凋亡率与对照组有显著性差异 (P <0 0 1)。结论 TNFα可诱导PC 3细胞的凋亡 。
出处
《江苏医药》
CAS
CSCD
北大核心
2003年第12期902-904,共3页
Jiangsu Medical Journal
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