机体非定位损伤分子标志的流行病学观察

The epidemiologic observation on molecular damages of human body

迄今关于大骨节病、克山病等地方病的研究 ,在临床诊断水平上的病因流行病学方面积累了一些经验 ,但当我们的视野扩展到“机体非定位损伤”的观察阶段 ,乃涉及分子损伤、分子生物标志等新的问题。本文旨在为此探索一条可循的技术路线 ,其中包括自身的若干经验 ,但主要的还是世界经验。作为基本内容是反应机体因内外环境因素所致分子损伤的生物标志和观察方法 ,主要是 :蛋白质的氧化损伤、脂肪的氧化损伤、DNA断裂及氧化损伤、C-反应蛋白、尿液微量白蛋白 ,以及这些标志的意义和研究方法。作者以为正确使用这些标志和方法 ,将为“真菌毒素与人类疾病研究”

In the processing for studying on causes of Ka schin-Beck Disease and Keshan disease, we accumulated some materials and work e xperiences. Up to now, our studies are based on the clinic or sub-clinic diagno se, but following the progressing to explore the pathogeneses of these diseases, we need to expand the vision field for involving the molecule damage into the s tudy scope. It is true that we must be reference to international generalized ex periences in medicine for founding of some suitable markers usable in epidemiolo gic studies. We holds that the non-orientation damages introduced by mycotoxins , known or unknown, can be expressed by some bio-markers notable as the protein oxide, the lipid oxide, the DNA damage, the C-reactive protein and the micro q uantities of albumin in urine, and so on. Of course, some other things must be i ncluded in this protocol also, they are methods detecting the markers from bio- samples and analyzing the relationship between causes and results. It is the tec hnical route for our study project to explore the etiology of “mycotoxin and hu man diseases”.