摘要
目的 :观察皮下脂膜炎样T细胞淋巴瘤 (SPTCL)的临床表现并分析SPTCL的病理组织学形态、诊断及鉴别诊断。方法 :报道 3例发生在四肢、躯干的多发性病灶的病例 ,从临床病理组织学及免疫组化、临床表现等方面进行了观察。结合文献 ,探讨SPTCL的发病学、临床表现、实验室检查、治疗及转归。结果 :SPTCL主要表现四肢、躯干皮肤水疱、皮下结节、多发溃疡。 2例合并噬血细胞综合征 ,临床进展迅速 ,于发病后 4个月及 8个月内死亡。组织病变均呈脂膜炎样改变 ,瘤细胞主要浸润皮肤真皮及皮下组织 ,瘤组织可见明显大片状坏死 ,肿瘤细胞浸润血管壁并见血管壁的凝固性坏死。免疫组化肿瘤细胞LCA、CD4 5R0阳性 ,证实瘤细胞为T细胞型。结论 :SPTCL是一种特殊类型的皮肤原发性恶性肿瘤 ,具有特殊生物学行为 。
Objective To analyzes the histopathological and clinical features for diagnosis of subcutaneous panniculitis like T cell lymphoma (SPTCL).Methods Clinicopatholgical changes,immmunophenotyping features and clinical features were studied in 3 cases of SPTCL.The pathogenesis,clinical features,laboratory findings,treatment and outcome of SPTCL are reviewed in this article.Results In the 3 cases of SPTCL,there were infiltration of atypical lymphocytes surrounding an adipose cell,in pannicultitis like pattern,in subcutaneous tissue.Aggressive necroses were found in the tumor.The tumor cells showed T cell phenotype.There was a complication of hemophagocytic syndrome in two cases,one died in 4 months,another died in 6 months.Conclusions SPTCL is a specific type of lymphoma involving primarily in subcutaneous fatty tissues.Prognosis was poor.
出处
《肿瘤防治杂志》
2003年第10期1090-1093,共4页
China Journal of Cancer Prevention and Treatment
关键词
淋巴瘤
T细胞
诊断
脂膜炎
病理学
皮肤肿瘤
诊断
T cell lymphoma
subcutaneous tissue
panniculitis
hemophagocytic syndrome
