奥沙利铂与氟尿嘧啶及亚叶酸钙联合治疗晚期大肠癌

Observation on Oxaliplatin Combined with Fluorouracil and Calcium Folinate in the Treatment of 40 Cases of Advanced Colorectal Cancer

目的 :研究奥沙利铂 (L OHP)与氟尿嘧啶 (5 FU)及亚叶酸钙 (CF)联合应用治疗晚期大肠癌的疗效和毒副反应。方法 :采用L OHP 130mg/m2 ,静脉滴入 2h ,d1;CF 2 0 0mg/m2 ,静脉滴入 2h ,d1～d5;5 FU 30 0mg/m2 (≤ 5 0 0mg/d) ,静脉滴入 4h ,d1～d5(CF滴完后 ) ;2 1d为 1个周期。结果 :总有效率为30 % ,毒副反应以骨髓抑制、感觉神经毒性为主 ,白细胞下降发生率为 4 5 % ,神经毒性发生率 80 % ,本组无Ⅳ度毒副反应。结论 :L OHP、5 FU、CF联合应用治疗晚期大肠癌疗效肯定 。

Objective To study the response and toxicity of the regimen of oxaliplatin combined with fluorouracil and calcium folinate in the treatment of advanced colorectal cancer.Methods:The regimen was oxaliplatin 130 mg/m 2 hours iv drip on the 1st day,calcium folinate 200 mg/m 2 iv drip 2 hours on days the 1st to 5 th ,followed by fluorouracil 300 mg/m 2(≤500 mg/d) iv drip 4 hours on the 1st to the 5 th ,and 21 days as one cycle.Results:The total response rate was 30%,the main toxicity was bone marrow suppression and neuro sensory toxicity.Leukopenia was observed in 45% of the patients,neuro sensory toxicity was observed in 80%.There was no toxicity and side effect of grade Ⅳ in these patients.Conclusions The regimen of oxaliplatin combined with fluorouracil and calcium folinate is effective and tolerable in advanced colorectal cancer therapy.