Syndecan-1和E-candherin在声门上型喉鳞状细胞癌中的表达及意义

The expression of cell adhesion molecule Syndecan-1 and E-candherin in laryngeal cancer

目的 :探讨Syndecan 1和E candherin两种黏附分子在声门上型喉鳞状细胞癌中的表达情况及与喉癌生物学行为之间的关系。方法 :应用SP免疫组织化学法检测了 38例声门上型喉鳞状细胞癌和 7例喉黏膜慢性炎症组织中的Syndecan 1和E candherin的表达并根据阳性瘤细胞占肿瘤细胞总数的比率进行半定量分析和统计检验。结果 :Syndecan 1和E candherin的阳性染色部位主要集中于细胞膜 ,E candherin也可表达于细胞间质。Syndecan 1和E candherin在恶性程度高的癌细胞上膜表达明显缺失 ,并与组织学分化、肿瘤大小密切相关。Syndecan 1和E candherin在喉鳞状细胞癌细胞上的表达结果有相关性 ,但无敏感性差异。 结论 :Syndecan 1和E candherin的表达可能在声门上型喉鳞状细胞癌的发生发展等生物学行为中起着重要的作用。

Objective:To observe Syndecan 1 and E candherin expression and their relationship with clinicopathologic factors in primary laryngeal squamous cell carcinoma(LSCC).Method:Syndecan 1 and E candherin proteins were determined with immunohistochemical technique.Result:In invasive LSCC the expression of these two adhesion molecules were very similar.Both diminished with decreasing cell differentiation,lacked often in poorly differentiated tumors.And their expression were significantly correlated with each other.Conclusion:Our results suggest that Syndecan 1 and E candherin expression correlates significantly with the histological differentiation grade of the tumors and the tumors size.They may play important roles in the pathogensis and the development of LSCC.