食管癌组织中多药耐药相关蛋白和CD44v6的表达

Expression of multidrug resistance-associated protein and CD44v6 in esophageal carcinoma

目的 探讨多药耐药相关蛋白 (multidrugresistance associatedprotein ,MRP)和CD44v6在食管癌组织中表达的意义 ,以及两者之间的关系。方法 采用免疫组织化学S P法检测 74例食管癌组织中MRP和CD44v6的蛋白表达。结果 MRP和CD44v6在食管癌组织中的阳性表达率分别为 5 1 4 %和 83 8%,食管癌中MRP的表达与肿瘤的浸润深度和淋巴结转移呈正相关 (P <0 0 5 ) ,而与肿瘤的分化程度无关 (P >0 0 5 )。CD44v6在食管癌中的表达与肿瘤的浸润深度和淋巴结转移密切相关 (P <0 0 5 ) ,而与肿瘤的分化程度无关 (P >0 0 5 )。CD44v6在MRP阳性食管癌中的表达明显高于其在MRP阴性食管癌中的表达 (P <0 0 5 )。结论 肿瘤多药耐药可能与肿瘤转移有关 ,检测食管癌中MRP和CD44v6的表达可能反映肿瘤细胞的生物学行为。

Purpose To study the expression of multidrug resistance-associated protein(MRP) and CD44v6 in esophageal carcinoma and their clinical significance and explore relationship between MRP with CD44v6. Methods MRP and CD44v6 expression were examined by S-P immunohistochemical technique in 74 cases of esophageal carcinoma. Results The positive rates of MRP and CD44v6 in esophageal carcinoma were 51.4% and 83.8% respectively. MRP expression was positive related to invasion and metastasis (P<0.05), but not correlation with differentiation in esophageal carcinoma. The positive expression of CD44v6 in esophageal carcinoma was correlation with invasion and metastasis(P<0.05), but not related to differentiation(P>0.05). CD44v6 expression in esophageal carcinoma with MRP positive expression was higher than that without MRP positive expression(P<0.05). Conclusions Multidrug resistance of tumor may be correlation with metastasis and the detection of MRP and CD44v6 may predict biological behavior in esophageal carcinoma.