桥本甲状腺炎伴甲状腺癌临床病理分析

Clinicopathological analysis of Hashimoto's thyroiditis with thyroid cancer

目的 探讨桥本甲状腺炎 (Hashimoto’sthyroiditis,HT)与甲状腺癌的关系。 方法 对 80例HT和其中 14例并发甲状腺癌的HE片进行形态学观察 ,部分病例进行PCNA、p5 3免疫组化标记。结果 HT及甲状腺癌旁组织有滤泡上皮细胞增生、乳头状增生、不典型增生至癌变移行 (过渡 )的形态 ,其PCNA表达逐渐增强 (P <0 0 1) ,p5 3在少数不典型增生及癌变区呈低度阳性表达 (P <0 0 5 )。结论 HT与甲状腺癌发生关系密切 ,HT中甲状腺滤泡上皮增殖活跃 ,易于癌变。HT是一种具有恶变潜能的病变 ,应引起高度重视。

Purpose To investigate the relationship and clinicopathologic significance of Hashimoto's thyroiditis(HT)and thyroid cancer. Methods Eighty cases of HT and 14 cases of HT associated thyroid caner were stained by HE and examined under light micoroscope. Some of tissues were studied by immunohistochemistry for PCNA and p53. Results The transformation from follicular epithelial cell hyperplasia,to papillary hyoerplasia to atypical hyperpiesia and to carcinomatous change was observed in the tissues from HT. Gradually enhanced expression of PCNA(P<0.01) was demonstrated in the above area and lower grade expression of p53 (P<0.05)was demonstrated in the area of atypically hyperplasion and carcinomatous change. Conclusions HT is closely associated with thyroid cancer.Active hyperplasia is showed and could malignant transformation in thyroid follicular epithelial cell in HT. HT is a potential malignant disease,and it should be paid more attention to.