新生儿胃-食管返流病的病理组织学研究

The Pathohistological Study of Gastro-esophageal Reflux Disease in Neonate

目的 :探讨新生儿胃 食管返流病的病理改变。方法 :分析新生儿 (6 0例 )尸检的食管形态学变化。结果 :本组食管炎 18例 (局灶性 10例 ,弥漫性 8例 )。肉眼示食管黏膜充血肿胀 ,糜烂及溃疡等改变。病理组织学检查属急性非特异性炎症 ,部份病例出现基底层细胞增生。 2例坏死性食管炎伴霉菌感染。本组多死于肺炎和败血症等并发症。结论 :新生儿胃_食管返流可以引起食管炎。由于其发生率较高 。

Objective:To study the pathological changes of gastro_esophageal reflux disease in neonate.Methods:The morphology changes of esophagus in 60 neonate by postmortem examination were analyzed.Results:Eighteen cases of esophagitis were found,in which, the lesions were local in 10 cases in the lower end of the esophagus and were diffuse in 8 cases.The congested swelling of the mucous membrane,superficial erosion and ulcer were seen in naked eye.The pathohistology examination was an acute nonspecific inflammation.The basal cell hyperplasia existed in some cases.Two cases of extensive necrotic esophagitis were associated with fungal infection.These cases died mainly in complication of neonatal pneumonia or septicemia.Conclusion: The neonatal esophagitis is caused by gastro_esophageal reflux. By its high incidence, it should be placed emphasis on antemortem diagnosis clinically.