摘要
目的:研究皮溃灵的药效和毒理作用。方法:观察皮溃灵对实验型皮肤溃疡的愈合效果,对巴豆油所致小鼠耳肿胀和角叉菜胶所致大鼠足跖肿胀的影响,对甲醛所致小鼠疼痛反应的影响,对小白鼠的急性毒性试验,对家兔正常皮肤和破损皮肤的刺激试验。结果:对实验型皮肤溃疡的愈合有明显的促进作用;对巴豆油所致小鼠耳肿胀、角叉菜胶所致大鼠足跖肿胀均有显著的抑制作用穴P<0.05~0.001雪;对甲醛所致小鼠疼痛反应有显著的止痛作用穴P<0.05~0.001雪。经7d的急性毒性试验,动物的饮食、外观、自发活动、粪便、生长发育未见明显影响,无一只动物死亡;家兔正常皮肤和皮肤破损试验也未见明显刺激作用。结论:皮溃灵具有显著的止痛、消炎、促进皮肤溃疡愈合的作用,对小鼠未见明显毒性。
bjective:To study the pharmacodynamics and toxicity of Pikuiling . Methods:Using the experimental models that swell in mouse resulted by croton oi l and CGN with Pikuiling to observe its affect and the reaction of mouse that ha d ached by formaldehyde.Taking the toxicity trial on mouse and stimulus reactio n trial on rabbits'normal and damaged skin.Results:Pikuiling has promtion to skin ulcers'healing and has inhibition to swelling(P<0.05~0.001)an d analgesic effect on models(P<0.05~0.001).After7days acute toxic ity trial,there were no obvious changes on models'appearance,behavior,feces and growth and no death occurred,no obvious irritation reaction occurred on ski n of rabbits.Conclusion:It is suggested that Pikuiling has obvious analgesic, anti-inflammation and healing to skin ulcers and has little side effect on mode ls.
出处
《中国药业》
CAS
2004年第4期38-40,共3页
China Pharmaceuticals
基金
重庆市卫生局中医药科研计划项目
No.2002-71
关键词
皮溃灵
药理学
毒理学
实验研究
Pikuiling
Pharmacology
Toxicology
Experimental Study