铝冶炼工人细胞遗传学监测

Cytogenetic Monitoring of Workers in the Aluminum Industry

本研究采用外周血淋巴细胞SCE 和MN 两项指标,对铝作业工人中的电解工和碳素工进行了细胞遗传学监测。结果表明,电解工和碳素工的SCE 频率分别为7.32和6.91SCE s/cell,显著高于对照组(5.73SCEs/cell,P<0.01,且电解与碳素工人间的SCE 频率也有显著性差异(P<0.05)。电解和碳素工人的微核细胞率分别为1.03‰和0.80‰,均显著高于对照(0.15‰),这些表明铝作业工人的细胞遗传物质受到了损伤,并且电解工受损程度高于碳素工。经用MMC 诱发后,碳素工人的诱发SCE频率(21.88SCE s/cell)与对照组(21.52SCE s/cell)比无显著性差异,而电解工的诱发SCE 频率(25.24SCE s/cell)与对照比仍有显著性差异(P<0.01),表明电解工的DNA 损伤修复系统功能有所降低。

Genetoxicity of peripheral lymphocytes in workers exposed to fluorideand coal tar pitch fumes in aluminum industry was conducted using sisterchromatid exchange(SCE)and micronucleus test(MNT).Results show-ed that the mean SCE frequencies of the electric smelting workers(7.32±0.31SCEs/cell)and coal tar pitch smelting workers(6.91±0.69SCEs/cell)were dramatically higher than that of the control(5.37±0.34 SCEs/cell).The micronucleus cells of the two exposed groups(1.02‰and 0.80‰,respectively)were significantly higher than that of thecontrol(0.15‰).These suggested that the pollutants in the aluminum pro-duction plant induced cytogenetic damage in the exposed workers.The SCEfrequency induced by mitomycin C(MMC)was increased significantly in allthree groups and significant difference was also seen between the group of elec-tric smelting workers and the control.These indicate that the function of DNArepair system has been reduced in electric smelting workers.