职业性中毒性肝病实验室诊断研究

Studies on Occupational Toxic Hepatopathy by Laboratory Tests

本文对临床已诊断为急、慢性中毒性肝病160例患者,进行了23种实验室肝脏功能试验研究。急性患者的肝功能试验阳性发生率为PA70%(14/20),ADA55%(4/20)、ALT45%(9/20),CG40%(8/20),与其余19种试验比较有显著差异(P<0.01)。对慢性患者,以ILG100%(11/11),ITTT45 64。75%(90/139),Tf 52。59%(71/135),CG31.75%(40/126)最为敏感,与常用肝功能的ALT 比较有显著差异(P<0.01)。中毒性肝病的检验阳性频率,急性病例有30%患者同时出现6种以上试验阳性。慢性病例有35%患者可同时出现4种以上试验阳性。肝脏功能试验的灵敏度,在急性病例血清酶和PA 检查出现明显的阳性,而在慢性病例以廓清试验(ICG,ITTT45)及Tf 最为敏感。

123 different laboratory tests were performed on 160 cases of acute andchronic occupational toxic hepatopathy.,Among 20 acute cases the followingpositive rats were found;PA 70%,ADA 55% ALT 45%,and CG 40%.Thaywere signficantly different with the other 19 laboratory tests(P<0.01).In thechronic cases,the follwing were more sensitive then the conventional ALT test;ICG 100%,ITTT45 64.75%,Tf 52.59%,and CG 31.75%(p<0.01).Generally,about 30% of acute cases showed positive results in more than 6tests,and about 35% of chronic cases showed positive results in 4 differenttests.Serem enzyme and PA tests were most sensitive in acute cases,and clear-ance(ICG and ITTT45)and Tf tests were most sensitive in chronic cases.